{"id":79651,"date":"2015-09-10T18:08:28","date_gmt":"2015-09-10T18:08:28","guid":{"rendered":"https:\/\/oglethorpe.edu\/faculty-list\/lea-marie-alford\/"},"modified":"2024-10-04T18:15:01","modified_gmt":"2024-10-04T18:15:01","slug":"lea-marie-alford","status":"publish","type":"faculty_list","link":"https:\/\/oglethorpe.edu\/es\/academicos\/facultad\/lea-marie-alford\/","title":{"rendered":"Lea Marie Alford"},"content":{"rendered":"\t\t
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Formaci\u00f3n:<\/strong>
Licenciatura, Universidad de Chicago
Doctorado, Boston College<\/p>\n

Honores y premios:
<\/strong>2022 Premio Lu Thomasson Garrett ’52 a la Ense\u00f1anza Meritoria
2009 Beca de Investigaci\u00f3n y Ense\u00f1anza de las Ciencias (FIRST), Premio NIH\/NIGMS al Desarrollo de la Carrera Institucional y Acad\u00e9mica (IRACDA).<\/p>\n

\u00c1reas de inter\u00e9s\/investigaci\u00f3n:
<\/strong>\u00abMi investigaci\u00f3n se centra en la biolog\u00eda ciliar utilizando el sistema gen\u00e9tico modelo Chlamydomonas reinhardtii. Visita el sitio web de nuestro laboratorio para obtener m\u00e1s informaci\u00f3n\u00bb<\/p>\n

P\u00e1gina web de la Facultad:
<\/strong>https:\/\/faculty.oglethorpe.edu\/lalford\/<\/a><\/p>\n

Cursos impartidos:
<\/strong>\u00abEnse\u00f1o en todos los niveles del plan de estudios del Programa de Biolog\u00eda, incluyendo Indagaci\u00f3n Biol\u00f3gica (BIO-110), Bioestad\u00edstica (BIO-111), Gen\u00e9tica (BIO-201) y asignaturas optativas avanzadas de biolog\u00eda celular y molecular. Tambi\u00e9n ense\u00f1o en el Programa Core, concretamente Ciencia y Naturaleza Humana (COR-400).\u00bb<\/p>\n

Publicaciones recientes:
<\/strong>*Coautora de la licenciatura<\/p>\n

Hwang, J., Yanagisawa, H., Davis, K.C., Hunter, E.L., Fox, L.A., *Jimenez, A.R., *Goodwin, R.E., *Gordon, S.A., *Stuart, C.D.E., Bower, R., Porter, M.E., Dutcher, S.K., Sale, W.S., Lechtreck, K.L., y Alford, L.M. Ensamblaje de FAP93 en el axonema proximal de los cilios de Chlamydomonas.
\nManuscrito en preparaci\u00f3n. <\/p>\n

Lechtreck, K., Liu, Y., Dai, J., Alkhofash, R.A., *Butler, J., Alford, L.M., Yang, P. Chlamydomonas ARMC2\/PF27 es un adaptador de carga obligado para el IFT de radios.
\neLife.
\n2022 11:e74993 \/\/doi.org\/10.7554\/eLife.74993 <\/p>\n

Alford, L.M., Brown, A., Yang, P. Los radios flagelares.
\nEn: Dutcher, S.K., Goodenough, U., Grossman, A., y Wollman, F.A. The Chlamydomonas Sourcebook Volume 3: Cell Motility and Behavior, 3\u00aa Ed.
\nCap\u00edtulo de libro invitado en prensa. <\/p>\n

Hunter, E.L., Lechtreck, K., Fu, G., Hwang, J., Lin, H., Gokhale, A., Alford, L.M., Lewis, B., Yamamoto, R., Kamiya, R., Yang, F., Nicastro, N., Dutcher, S.K., Wirschell, M., Sale, W.S. El adaptador IDA3, necesario para el transporte intraflagelar de la dine\u00edna I1, est\u00e1 regulado por la longitud ciliar.
\nMol.
\nBiol.
\nCell.
\n2018.
\nApr 15;29(8):886-896 doi: 10.1091\/mbc.E17-12-0729 PMID: 29467251. <\/p>\n

Yamamoto, R., Obbineni, J.M., Alford, L.M., Ide, T., Owa, M., Hwang, J., Kon, T., Inaba, K., James, N., King, S.M., Ishikawa, T., Sale, W.S., Dutcher, S.K. Chlamydomonas DYX1C1\/PF23 es esencial para el ensamblaje axonemal y la morfolog\u00eda adecuada de los brazos internos de dine\u00edna.
\nPLoS Genetics.
\n2017.
\nSep 11;13(9):e1006996.
\ndoi: 10.1371\/journal.pgen.1006996. <\/p>\n

Hunter, E.L., Sale, W.S., Alford, L.M. An\u00e1lisis del ensamblaje axonemal durante la regeneraci\u00f3n ciliar en Chlamydomonas.
\nM\u00e9todos Mol Biol.
\n2016;1454:237-43.
\ndoi: 10.1007\/978-1-4939-3789-9_15.
\nPMID:27514926 <\/p>\n

Alford, L.M., Stoddard, D., Li, J.H., Hunter, E.L., Tritschler, D., Bower, R., Nicastro, D., Porter, M.E., Sale, W.S. El enlace nexina y la poliglutamilaci\u00f3n de los t\u00fabulos B mantienen la alineaci\u00f3n de los dobletes externos en el axonema ciliar.
\nCitoesqueleto.
\n2016.
\n22 abr.
\ndoi:10.1002\/cm.21301.
\nPMID: 27105591 <\/p>\n

Vasudevan, K.K., Song, K., Alford, L.M., Sale, W.S., Dymek, E.E., Smith, E.F., Hennessey, T., Joachimiak E., Urbanska, P., Wloga, D., Dentler, W., Nicastro, D., Gaertig, J. FAP206 es un adaptador de acoplamiento de microt\u00fabulos para el radio ciliar 2 y la dine\u00edna c.
\nMol Biol Cell.
\n2015.
\nFeb 15;26(4):696-710.
\ndoi: 10.1091\/mbc.E14-11-1506.
\nPMID: 25540426 <\/p>\n

Vasudevan, K.K., Jiang, P.Y., Lechtreck, K.F., Kushida, Y., Alford, L.M., Sale, W.S., Hennessey, T., Gaertig, J. La kinesina-13 regula la cantidad y la calidad de la tubulina en el interior de los cilios.
\nMol Biol Cell.
\n2015.
\nFeb 1;26(3):478-94.
\ndoi: 10.1091\/mbc.E14-09-1354.
\nPMID: 25501369 <\/p>\n

Viswanadha, R., Hunter, E.L., Yamamoto, R., Wirschell, M., Alford, L.M., Sale, W.S. El brazo interno ciliar de la dine\u00edna, I1, se ensambla en el citoplasma antes de ser transportado por IFT para el acoplamiento axonemal.
\nCitoesqueleto.
\n2014.
\nOct;71(10):573-86.
\ndoi: 10.1002\/cm.21192.
\nPMID: 25252184 <\/p>\n

Alford, L.M., Mattheyses, A.L., Hunter, E.L., Lin, H., Dutcher, S., Sale, W.S. El mutante pf27 de Chlamydomonas revela nuevas caracter\u00edsticas del ensamblaje de los radios ciliares.
\nCitoesqueleto.
\n2013.
\nDic;70(12):804-18.
\ndoi: 10.1002\/cm.21144.
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